How Nicotine Affects the Developing Adolescent Brain

Ask the Experts | Miriam Mandel, MD

Nicotine affects the neural reward pathways in the adult brain differently than in the rapidly developing adolescent brain.

Since vape devices can deliver nicotine on demand, that means these kids are getting a substantial amount of dopamine released from this circuitry on demand as well.

The young brain (especially vulnerable under 15) is wired to expect that dopamine surge.

This is not how nature intended it.

Surges of dopamine that are being given to the brain through drugs and alcohol (or any other addictive behavior) are being wired to expect that dopamine on schedule.

Most kids who vape do so often to maintain high levels of dopamine.

The half-life of nicotine is 2 hours, but the body starts to feel the tapering of it after 30-45 minutes, and this is why some kids have a hard time stilling in a 60 or 90-minute class without needing to get up, head to the bathroom and hit their vape.

The body expects it and demands it.

If it is not satisfied and the nicotine schedule is off, they will start to exhibit the universal signs of withdrawal, which are:
1. dysphoria (discomfort, unease, distress)
2. irritability
3. anxiety
4. insomnia

If you notice any of these symptoms come on suddenly in your child, ask them about it.

Chances are they don’t really know what’s going on.

Many kids have no idea how addictive this is and think they can control it or quit anytime.

Chances are, they can’t. But there are ways you can help.


Miriam Mandel, MD is pediatrician, teen health and wellness coach, and school consultant. Her passion is teaching individuals, especially teens and their families, to look for the answers they are seeking inside, where all the answers lie.